Production of an Attenuated Phenol-Soluble Modulin Variant Unique to the MRSA Clonal Complex 30 Increases Severity of Bloodstream Infection

@inproceedings{Cheung2014ProductionOA,
  title={Production of an Attenuated Phenol-Soluble Modulin Variant Unique to the MRSA Clonal Complex 30 Increases Severity of Bloodstream Infection},
  author={Gordon Y C Cheung and Dorothee Kretschmer and Anthony C. Duong and Anthony J. Yeh and Trung V. Ho and Yan Chen and Hwang-Soo Joo and Barry Kreiswirth and Andreas Peschel and Michael Otto},
  booktitle={PLoS pathogens},
  year={2014}
}
Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of morbidity and death. Phenol-soluble modulins (PSMs) are recently-discovered toxins with a key impact on the development of Staphylococcus aureus infections. Allelic variants of PSMs and their potential impact on pathogen success during infection have not yet been described. Here we show that the clonal complex (CC) 30 lineage, a major cause of hospital-associated sepsis and hematogenous complications, expresses an allelic… CONTINUE READING
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