Production of active pediocin PA-1 in Escherichia coli using a thioredoxin gene fusion expression approach: cloning, expression, purification, and characterization.

@article{Beaulieu2007ProductionOA,
  title={Production of active pediocin PA-1 in Escherichia coli using a thioredoxin gene fusion expression approach: cloning, expression, purification, and characterization.},
  author={Lucie Beaulieu and Dmitri Tolkatchev and Jean-François Jett{\'e} and Denis Groleau and Muriel Subirade},
  journal={Canadian journal of microbiology},
  year={2007},
  volume={53 11},
  pages={
          1246-58
        }
}
Antimicrobial peptides possess cationic and amphipathic properties that allow for interactions with the membrane of living cells. Bacteriocins from lactic acid bacteria, in particular, are currently being studied for their potential use as food preservatives and for applications in health care. However, bacteriocin exploitation is often limited owing to low production yields. Gene cloning and heterologous protein or peptide production is one way to possibly achieve overexpression of… CONTINUE READING
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