• DOI:10.1007/s10295-016-1843-6
Corpus ID: 24472338

Production of acrylic acid and propionic acid by constructing a portion of the 3-hydroxypropionate/4-hydroxybutyrate cycle from Metallosphaera sedula in Escherichia coli

@article{Liu2016ProductionOA,
  title={Production of acrylic acid and propionic acid by constructing a portion of the 3-hydroxypropionate/4-hydroxybutyrate cycle from Metallosphaera sedula in Escherichia coli},
  author={Z. Liu and Tiangang Liu},
  journal={Journal of Industrial Microbiology & Biotechnology},
  year={2016},
  volume={43},
  pages={1659-1670}
}

Z. Liu, Tiangang Liu

Published 2016

Biology, Medicine

Journal of Industrial Microbiology & Biotechnology

Acrylic acid and propionic acid are important chemicals requiring affordable, renewable production solutions. [...] Key Method To construct an acrylic acid-producing pathway in E. coli, heterologous expression of malonyl-CoA reductase (MCR), malonate semialdehyde reductase (MSR), 3-hydroxypropionyl-CoA synthetase (3HPCS), and 3-hydroxypropionyl-CoA dehydratase (3HPCD) from M. sedula was accompanied by overexpression of succinyl-CoA synthetase (SCS) from E. coli. The engineered strain produced 13.28 ± 0.12 mg/L…Expand Abstract

View on Springer

ncbi.nlm.nih.gov

Save to Library

Create Alert

Cite

Launch Research Feed