Production of acrylic acid and propionic acid by constructing a portion of the 3-hydroxypropionate/4-hydroxybutyrate cycle from Metallosphaera sedula in Escherichia coli

@article{Liu2016ProductionOA,
  title={Production of acrylic acid and propionic acid by constructing a portion of the 3-hydroxypropionate/4-hydroxybutyrate cycle from Metallosphaera sedula in Escherichia coli},
  author={Z. Liu and Tiangang Liu},
  journal={Journal of Industrial Microbiology & Biotechnology},
  year={2016},
  volume={43},
  pages={1659-1670}
}
  • Z. Liu, Tiangang Liu
  • Published 2016
  • Biology, Medicine
  • Journal of Industrial Microbiology & Biotechnology
  • Acrylic acid and propionic acid are important chemicals requiring affordable, renewable production solutions. [...] Key Method To construct an acrylic acid-producing pathway in E. coli, heterologous expression of malonyl-CoA reductase (MCR), malonate semialdehyde reductase (MSR), 3-hydroxypropionyl-CoA synthetase (3HPCS), and 3-hydroxypropionyl-CoA dehydratase (3HPCD) from M. sedula was accompanied by overexpression of succinyl-CoA synthetase (SCS) from E. coli. The engineered strain produced 13.28 ± 0.12 mg/L…Expand Abstract
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