Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing

@article{Rosenfeld1983ProductionOA,
  title={Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing},
  author={M. Rosenfeld and J. Mermod and S. Amara and L. Swanson and P. Sawchenko and J. Rivier and W. Vale and R. Evans},
  journal={Nature},
  year={1983},
  volume={304},
  pages={129-135}
}
  • M. Rosenfeld, J. Mermod, +5 authors R. Evans
  • Published 1983
  • Chemistry, Medicine
  • Nature
  • Alternative processing of the RNA transcribed from the calcitonin gene appears to result in the production of a messenger RNA in neural tissue distinct from that in thyroidal ‘C’ cells. The thyroid mRNA encodes a precursor to the hormone calcitonin whereas that in neural tissues generates a novel neuropeptide, referred to as calcitonin gene-related peptide (CGRP). The distribution of CGRP-producing cells and pathways in the brain and other tissues suggests functions for the peptide in… CONTINUE READING
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