Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing
@article{Rosenfeld1983ProductionOA, title={Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing}, author={M. Rosenfeld and J. Mermod and S. Amara and L. Swanson and P. Sawchenko and J. Rivier and W. Vale and R. Evans}, journal={Nature}, year={1983}, volume={304}, pages={129-135} }
Alternative processing of the RNA transcribed from the calcitonin gene appears to result in the production of a messenger RNA in neural tissue distinct from that in thyroidal ‘C’ cells. The thyroid mRNA encodes a precursor to the hormone calcitonin whereas that in neural tissues generates a novel neuropeptide, referred to as calcitonin gene-related peptide (CGRP). The distribution of CGRP-producing cells and pathways in the brain and other tissues suggests functions for the peptide in… CONTINUE READING
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