Production of a novel monoclonal antibody, JT-95, which can detect antigen of thyroid carcinoma.

@article{Takeyama1996ProductionOA,
  title={Production of a novel monoclonal antibody, JT-95, which can detect antigen of thyroid carcinoma.},
  author={Hiroshi Takeyama and Tomonori Hosoya and Kensuke Sakurai and Yuya Mori and Masashi Watanabe and Hisanobu Kisaki and Takatoshi Ohno},
  journal={Cancer research},
  year={1996},
  volume={56 8},
  pages={
          1817-22
        }
}
Monoclonal antibody (MAb) JT-95 was produced by immunization of mice with membrane fractions of a human thyroid carcinoma. Immuno-histochemical staining has demonstrated that the antigen recognized by JT-95 is strongly expressed in 95 (95%) of 100 cases of papillary carcinomas and in 3 (75%) of 4 cases of follicular carcinomas. In benign diseases of the thyroid gland, MAb JT-95 reacted with 0 (0%) of 39 adenomas, 1 (4%) of 21 adenomatous goiters, 0 (0%) of 8 hyperthyroidism specimens, and 3 (38… CONTINUE READING