Production of a non-functional nef protein in human immunodeficiency virus type 1-infected CEM cells.

Abstract

The nef gene product of the human immunodeficiency virus (HIV) is suggested to be a negative factor involved in down-regulating viral expression by a mechanism in which the correct conformation of the nef protein is essential. The nef protein expressed by vaccinia virus recombinants is phosphorylated by protein kinase C. We investigated the synthesis of the… (More)

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@article{Laurent1990ProductionOA, title={Production of a non-functional nef protein in human immunodeficiency virus type 1-infected CEM cells.}, author={A G Laurent and Ara G. Hovanessian and Yves Rivi{\`e}re and Bernard Krust and Armelle R{\'e}gnault and Luc Montagnier and Annie Findeli and M. P. Kieny and Benrubi Guy}, journal={The Journal of general virology}, year={1990}, volume={71 ( Pt 10)}, pages={2273-81} }