Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation.

@article{Gerdes1983ProductionOA,
  title={Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation.},
  author={Johannes Gerdes and Ulrich Schwab and H. Michael Lemke and Harald Von Stein},
  journal={International journal of cancer},
  year={1983},
  volume={31 1},
  pages={13-20}
}
The production of a mouse monoclonal antibody, Ki-67, is described. The Ki-67 antibody recognized a nuclear antigen present in proliferating cells, but absent in resting cells. Immunostainings with Ki-67 revealed nuclear reactivity in cells of germinal centres of cortical follicles, cortical thymocytes, neck cells of gastrointestinal mucosa, undifferentiated spermatogonia and cells of a number of human cell lines. The Ki-67 antibody did not react with cells known to be in a resting stage, such… CONTINUE READING
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