Production of a hypoglycemic, extracellular polysaccharide from the submerged culture of the mushroom, Phellinus linteus

  title={Production of a hypoglycemic, extracellular polysaccharide from the submerged culture of the mushroom, Phellinus linteus},
  author={Dong-Hyun Kim and Byung-Keun Yang and Sang Chul Jeong and Jun-Bo Park and Sung-Pill Cho and Surajit Das and Jong Won Yun and Chi-Hyun Song},
  journal={Biotechnology Letters},
Mycelial growth and extracellular polysaccharide production of Phellinus linteus were optimal at pH 5 and 25 °C. Maximum biomass production (14.2 g l−1) was after 15 d of cultivation, whereas, extracellular polysaccharide was maximal (3.5 g l−1) after 21 d. The hypoglycemic effect of the polysaccharide, investigated in streptozotocin-induced diabetic rats, decreased plasma glucose, total cholesterol and triacylglycerol concentrations by 49%, 32%, and 28%, respectively, and aspartate… 
Production of Polysaccharide by the Edible Mushroom, Grifola frondosa
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Quantitative response of cell growth and polysaccharide biosynthesis by the medicinal mushroom Phellinus linteus to NaCl in the medium
The effect of NaCl on cell growth and polysaccharide biosynthesis in the medicinal mushroom Phellinus linteus was studied. With the increase of NaCl concentration between 1 g/l and 7 g/l in the
Polysaccharides production by submerged fermentation of Coprinus comatus and their inhibitory effects on non-enzymatic glycosylation
The findings in this study can be applied to improve the performance of C. comatus cultures in the production of bioactive metabolites on a bioreactor scale and provide a foundation for further investigation into medicinally active compounds derived from C.Comatus.
Production of Exopolysaccharides from Submerged Culture of Antrodia Camphorata S-29
The baseline information about production conditions for this specific specie is provided which is crucial data to know before any further studies as it determines the properties and quantity of the desired produced specie.
Submerged culture conditions were studied for the production of Exo & Endo polysaccharide (EPS, IPS) from Sparassis crispa and 7 days was found to be sufficient for obtaining good amount of biomass as its rate of increase was high with a very low increase thereafter.
Production of Anti-Complementary Exopolysaccharides from Submerged Culture of Flammulina velutipes
Results of tests on the anti-complementary activity in the absence of Ca 2+ and immunoelectrophoresis indicated that the mode of complement activation by exopolysaccharide from F. velutipes is via both the classical and alternative pathways and that the activation degree is almost the same in each pathway.


Effect of cultural conditions on polysaccharide production and its monosaccharide composition in Phellinus linteus L13202
The effect of cultural conditions on mycelial growth, polysaccharide production in Phellinus linteus and its monosaccharide composition was studied. P. linteus showed the highest growth (0.9 g/100
Studies on the main factors affecting the mycelial growth of Phellinus linteus.
This study was carried out to obtain the basic data on artificial culture of Phellinus linteus. The optimum condition for the mycelial growth was and pH . The carbon sources such as D-glucose,
Polysaccharides in fungi. XXXVIII. Anti-diabetic activity and structural feature of a galactomannan elaborated by Pestalotiopsis species.
A fungus of Pestalotiopsis species produced an extracellular, water-soluble polysaccharide (PS-N). PS-N exhibited significant hypoglycemic activity in streptozotocin-induced diabetic mice following
Insulin-releasing and insulin-like activity of Agaricus campestris (mushroom).
The presence of antihyperglycaemic, insulin-releasing and insulin-like activity in A. campestris is demonstrated and is demonstrated to be due to a lectin-mediated event.
Anti-complementary activity of endopolymers produced from submerged mycelial culture of higher fungi with particular reference to Lentinus edodes
The anti-complementary activity (immuno-stimulating activity) of endo-polymer produced from submerged mycelial cultures of 21 types of higher fungi showed the highest (85%) followed by Flammulina velutipes and Phellinus linteus.
Hyperlipoproteinemia in Streptozotocin-treated Rats
The diabetes produced by streptozotocin administration to sucrose-fed rats provides a useful model for the study of the hyperlipoproteinemia of diabetes.
Cytoprotective effect of the prostacyclin derivative iloprost against liver cell death induced by the hepatotoxins carbon tetrachloride and bromobenzene.
It is concluded that the prostacyclin derivative Iloprost possesses cytoprotective activity on rat hepatocytes against lethal injury by CCl4 or BB.