Production of a high concentration acetic acid by Acetobacter aceti using a repeated fed-batch culture with cell recycling

@article{Park2004ProductionOA,
  title={Production of a high concentration acetic acid by Acetobacter aceti using a repeated fed-batch culture with cell recycling},
  author={Yong Soo Park and Kiyoshi Toda and Masahiro Fukaya and Hajime Okumura and Yoshiya Kawamura},
  journal={Applied Microbiology and Biotechnology},
  year={2004},
  volume={35},
  pages={149-153}
}
The acetic acid concentration in a batch culture of Acetobacter aceti M23 increased up to 90 g/l by adding ethanol intermittently. Although the bacterial cells ceased growth at about 60 g acetic acid/l, non-viable cells still preserved ethanol oxidation activity. Cell recycling by filtration in a repeated fed-batch culture increased the overall acetic acid production rate 2.84-fold compared to that without cell recycling for the purpose of obtaining an acetic acid concentration of 80.8 g/l… CONTINUE READING