Production of a fusion protein consisting of the enterotoxigenic Escherichia coli heat-labile toxin B subunit and a tuberculosis antigen in Arabidopsis thaliana

@article{Rigano2004ProductionOA,
  title={Production of a fusion protein consisting of the enterotoxigenic Escherichia coli heat-labile toxin B subunit and a tuberculosis antigen in Arabidopsis thaliana},
  author={Maria Manuela Rigano and Maria Lucrecia Alvarez and Julia Pinkhasov and Y. Jin and Francesco Sala and Charles J. Arntzen and Amanda Maree Walmsley},
  journal={Plant Cell Reports},
  year={2004},
  volume={22},
  pages={502-508}
}
Transgenic plants are potentially safe and inexpensive vehicles to produce and mucosally deliver protective antigens. However, the application of this technology is limited by the poor response of the immune system to non-particulate, subunit vaccines. Co-delivery of therapeutic proteins with carrier proteins could increase the effectiveness of the antigen. This paper reports the ability of transgenic Arabidopsis thaliana plants to produce a fusion protein consisting of the B subunit of the… CONTINUE READING

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