Production of Two Novel Methoxy-Isoflavones from Biotransformation of 8-Hydroxydaidzein by Recombinant Escherichia coli Expressing O-Methyltransferase SpOMT2884 from Streptomyces peucetius

@article{Chiang2015ProductionOT,
  title={Production of Two Novel Methoxy-Isoflavones from Biotransformation of 8-Hydroxydaidzein by Recombinant Escherichia coli Expressing O-Methyltransferase SpOMT2884 from Streptomyces peucetius},
  author={C. Chiang and Hsiou-Yu Ding and Ya-Ting Tsai and T. Chang},
  journal={International Journal of Molecular Sciences},
  year={2015},
  volume={16},
  pages={27816 - 27823}
}
  • C. Chiang, Hsiou-Yu Ding, +1 author T. Chang
  • Published 2015
  • Biology, Medicine
  • International Journal of Molecular Sciences
  • Biotransformation of 8-hydroxydaidzein by recombinant Escherichia coli expressing O-methyltransferase (OMT) SpOMT2884 from Streptomyces peucetius was investigated. Two metabolites were isolated and identified as 7,4′-dihydroxy-8-methoxy-isoflavone (1) and 8,4′-dihydroxy-7-methoxy-isoflavone (2), based on mass, 1H-nuclear magnetic resonance (NMR) and 13C-NMR spectrophotometric analysis. The maximum production yields of compound (1) and (2) in a 5-L fermenter were 9.3 mg/L and 6.0 mg/L… CONTINUE READING
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