Production of TNF-alpha and bone resorbing activity by macrophages in response to different types of bone cement particles.

@article{Ingham2000ProductionOT,
  title={Production of TNF-alpha and bone resorbing activity by macrophages in response to different types of bone cement particles.},
  author={Eileen Ingham and Tara R Green and Martin Stone and Rick S Z Kowalski and N. Watkins and John Berton Fisher},
  journal={Biomaterials},
  year={2000},
  volume={21 10},
  pages={1005-13}
}
We have compared the capacity of clinically relevant wear debris from seven different cement types to activate macrophages to produce TNF-alpha, IL-1beta, IL-6 and bone resorbing activity in vitro. The bone cements were: CMW 1 original (PMMA only); CMW 1RO (1 microm BaSO4; 9.2%); CMW copolymer bone cement 1 (10 microm BaSO4; 10%); CMW copolymer bone cement 2 (1 microm BaSO4; 10%); Palacos R (10 microm ZrO2; 15.6%); CMW Calcium phosphate cement 20% (10 microm tri-calcium phosphate; 20%) and CMW… CONTINUE READING
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