Production of Monoclonal Antibodies to Pathologic β-sheet Oligomeric Conformers in Neurodegenerative Diseases

@inproceedings{Sez2017ProductionOM,
  title={Production of Monoclonal Antibodies to Pathologic β-sheet Oligomeric Conformers in Neurodegenerative Diseases},
  author={Ferm{\'i}n Go{\~n}i S{\'a}ez and Mitchell Mart{\'a}-Ariza and Daniel Kevin Peyser and Krystal Herline and Thomas Wisniewski},
  booktitle={Scientific Reports},
  year={2017}
}
We describe a novel approach to produce conformational monoclonal antibodies selected to specifically react with the β-sheet secondary structure of pathological oligomeric conformers, characteristic of many neurodegenerative diseases. Contrary to past and current efforts, we utilize a mammalian non-self-antigen as an immunogen. The small, non-self peptide selected was covalently polymerized with glutaraldehyde until it reached a high β-sheet secondary structure content, and species between 10… CONTINUE READING
BETA

References

Publications referenced by this paper.
SHOWING 1-10 OF 61 REFERENCES

Alzheimer’s disease

P Scheltens
  • Lancet 388,
  • 2016

An Oral Abeta Vaccine Using a Recombinant AdenoAssociated Virus Vector in Aged Monkeys : Reduction in Plaque Amyloid and Increase in Abeta Oligomers

H. Hara
  • J Alzheimers Dis
  • 2016

Pathological alpha - synuclein transmission initiated by binding lymphocyteactivation gene 3

X. Mao
  • Science
  • 2016

Pathological alpha-synuclein transmission initiated by binding lymphocyte-activation gene

X Mao
  • Science
  • 2016

Reduction in Plaque Amyloid and Increase in Abeta Oligomers

Hara, H. et al. An Oral Abeta Vaccine Using a Recombinant A Monkeys
  • J Alzheimers Dis 54, 1047–1059
  • 2016

Tau Structures

J Avila
  • Front Aging Neurosci 8,
  • 2016

Similar Papers

Loading similar papers…