Production of Interferon‐α/β by Murine Dendritic Cell Lines Stimulated by Virus and Bacteria

@article{Eloranta1997ProductionOI,
  title={Production of Interferon‐$\alpha$/$\beta$ by Murine Dendritic Cell Lines Stimulated by Virus and Bacteria},
  author={M L Eloranta and Kristian Sandberg and Paola Ricciardi-Castagnoli and Mats Lindahl and G. V. Alm},
  journal={Scandinavian Journal of Immunology},
  year={1997},
  volume={46}
}
The interferon‐α and ‐β (IFN‐α/β) producing ability of the two murine dendritic cell (DC) lines D2SC/1 and FSDC was studied. The D2SC/1 cells produced IFN‐α and ‐β when stimulated by herpes simplex virus (HSV), Sendai virus (SV) or by the bacteria Escherichia coli or Staphylococcus aureus Cowan I. Precultivating (priming) D2SC/1 cells with recombinant IFN‐β or a combination of IFN‐β and granulocyte–macrophage colony‐stimulating factor increased production of IFN‐α/β induced by HSV or the… 
Low Levels of Interferon‐α Induce CD86 (B7.2) Expression and Accelerates Dendritic Cell Maturation from Human Peripheral Blood Mononuclear Cells
TLDR
The results suggest that IFN‐α is a potent accelerator of DC maturation in vitro, which may explain its clinical success in the treatment of cancer and viral infection as well as its ability to promote autoimmunity.
IL-4 Suppresses Dendritic Cell Response to Type I Interferons1
TLDR
IL-4 renders myeloid DCs less responsive to paracrine type I IFNs and less potent in sustaining the autocrine positive loop that normally amplifies the effects of type IIFNs, which could explain the increased susceptibility to viral infections observed during Th2-inducing parasitoses.
Splenic Marginal Metallophilic Macrophages and Marginal Zone Macrophages are the Major Interferon‐α/β Producers in Mice upon Intravenous Challenge with Herpes Simplex Virus
TLDR
It is concluded that the massive IFN‐α/β production in the MZ of the spleen upon in vivo stimulation by HSV is mainly exerted by marginal metallophilic macrophage and to a lesser extent by MZ macrophages.
Upregulation of interleukin-4 and IFN-gamma expression by IFN-tau, a member of the type I IFN family.
TLDR
It is demonstrated thatIFN-tau is an immunomodulatory cytokine that promotes enhanced IL-4 and IFN-gamma responses by effector T cells but not, strictly speaking, Thl-biased responses in cattle.
The role of type I interferons in non‐viral infections
TLDR
This review summarizes the current knowledge on the production and function of IFN‐α/β during non‐viral infections in vitro and in vivo.
IL-15 Is Expressed by Dendritic Cells in Response to Type I IFN, Double-Stranded RNA, or Lipopolysaccharide and Promotes Dendritic Cell Activation1
TLDR
IL-15 is identified as a stimulatory cytokine for DCs with the potential for autocrine activity and its effects to expression of IFN-αβ are linked.
Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology
TLDR
It is shown that mouse interferon-α–producing cells (mIPCs) are a unique subset of immature antigen-presenting cells (APCs) that secrete IFN-α upon stimulation with viruses and interleukin 12 (IL-12) in response to viruses and CpG oligodeoxynucleotides, but not bacterial products.
IFN‐α enhances CD40 ligand‐mediated activation of immature monocyte‐derived dendritic cells
TLDR
The results suggest that the rapid expression of CD40L, IFN and IL-1beta at sites of infection and inflammation can act in concert on immature DC, thereby linking innate and adaptive immune responses.
IFN‐γ Production and Degranulation are Differentially Regulated in Response to Stimulation in Murine Natural Killer Cells
TLDR
Study of cell surface mobilization of a molecule present in secretory lysosomes, CD107a (LAMP‐1), to monitor the relationship between degranulation of NK cells and their production of IFN‐γ at the single cell level revealed that immature NK cells are preferentially degranulating, Mac‐1loCD27hi cells perform both effector functions efficiently, while the most mature NK cells display reduced degranulated but with maintained IFN-γ production.
Type I interferons produced by dendritic cells promote their phenotypic and functional activation.
TLDR
It is shown that murine DCs undergo phenotypic maturation upon exposure to type I interferons (type I IFNs) in vivo or in vitro, identifying type Iinterferons as autocrine DC activators.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 43 REFERENCES
Interferons and the Colony‐Stimulating Factors IL‐3 and GM‐CSF Enhance the IFN‐α Response in Human Blood Leucocytes Induced by Herpes Simplex Virus
TLDR
The results suggest that cytokines such as the CSFs and IFNs may be involved in the regulation of NIP cell functions.
Modulation of cytokine expression in mouse dendritic cell clones
TLDR
The results suggest that DC have a limited cytokine gene expression pattern compared to macrophages and are heterogenous in some functional properties.
The Cell Surface Phenotype of Human Natural Interferon‐α Producing Cells as Determined by Flow Cytometry
TLDR
The HSV‐IPC in many respects resemble immature DC, but clearly differ from typical mature DC, however, they may also represent a specialized population of efficient IFN‐α producing cells.
Interleukin‐12 is produced by dendritic cells and mediates T helper 1 development as well as interferon‐γ production by T helper 1 cells
TLDR
DC exhibited features that had not been seen with other antigen‐presenting cells: they produced bioactive IL‐12 upon antigen‐specific interaction with T cells without any other stimuli; in an allogeneic mixed leukocyte reaction model, neutralizing anti‐IL‐12 antibodies showed that DC‐derived IL‐ 12 was critical for optimal proliferation and IFN‐γ production by activated Th1 blasts.
Viral Induction of Low Frequency Interferon-α Producing Cells
TLDR
It is concluded that low frequency, nonmonocytic NIPC account for the majority of IFN-alpha production in response to different viruses.
Role of interferons and other cytokines in the regulation of the immune response
  • F. Belardelli
  • Biology
    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • 1995
TLDR
Recent data indicate that these molecules (especially IFNs‐α) specifically promote the differentiation towards the Th1‐type response, which emphasizes the importance of macrophage‐cytokine interactions in determining the type of immune response.
Characterization of Rat Monoclonal Antibodies to Mouse Interferon-α and -β
TLDR
Preparation of rat monoclonal antibodies to mouse IFN-α and -β, and initial characterization of their properties are described.
Different cytokines regulate antigen uptake and presentation of a precursor dendritic cell line
TLDR
The results suggest that antigen uptake and antigen presentation in DC are regulated by different cytokine signals provided by the surrounding tissue.
Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo
TLDR
In mice, IFN I [poly(I:C)]-stimulated CD8+ cells survived for prolonged periods in vivo and displayed the same phenotype as did long-lived antigen-specific CD8-specific cells, and production ofIFN I may play an important role in the generation and maintenance of specific memory.
Expression of cytokine mRNA by human peripheral blood dendritic cells stimulated with human immunodeficiency virus and herpes simplex virus.
TLDR
It is demonstrated by using a bioassay that DC purified from human blood are the major producers of interferon-a (IFN-α) in response to HIV-1 and herpes simplex virus (HSV).
...
1
2
3
4
5
...