Production of IL-12, IL-18 and TNF-alpha by alveolar macrophages in hypersensitivity pneumonitis.

@article{Chen2004ProductionOI,
  title={Production of IL-12, IL-18 and TNF-alpha by alveolar macrophages in hypersensitivity pneumonitis.},
  author={Baomin Chen and Zhaohui Tong and Shinobu Nakamura and Ulrich Costabel and Josune Guzman},
  journal={Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG},
  year={2004},
  volume={21 3},
  pages={199-203}
}
BACKGROUND AND AIM OF THE WORK Hypersensitivity pneumonitis (HP) is characterized by a macrophage-lymphocyte alveolitis and granuloma formation. A wide range of cytokines have been implicated in the pathophysiology and development of granulomas in HP, but there is no information about the production of interleukin-12 (IL-12) and IL-18 by alveolar macrophages (AM) in human HP. We evaluated whether the production of IL-12, IL-18 and tumor necrosis factor-alpha (TNF-alpha) is locally increased in… CONTINUE READING