Production of Human Tissue Plasminogen Activator in Transgenic Mouse Milk

@article{Gordon1987ProductionOH,
  title={Production of Human Tissue Plasminogen Activator in Transgenic Mouse Milk},
  author={K. Gordon and E. Lee and J. A. Vitale and A. Smith and H. Westphal and L. Hennighausen},
  journal={Bio/Technology},
  year={1987},
  volume={5},
  pages={1183-1187}
}
  • K. Gordon, E. Lee, +3 authors L. Hennighausen
  • Published 1987
  • Biology, Medicine
  • Bio/Technology
    • We set out to express an exogenous gene in the mammary epithelium of transgenic mice in the hope that the encoded protein would be secreted into milk. The promoter and upstream regulatory sequences from the murine whey acid protein (WAP) gene were fused to cDNA encoding human tissue plasminogen activator (t–PA) with its endogenous secretion signal sequence. This hybrid gene was injected into mouse embryos, resultant transgenic mice were mated, and milk obtained from lactating females was shown… CONTINUE READING
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    191 Citations
    Background Citations
    30
    Methods Citations
    5
    191 Citations
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