Production of H5N1 (NIBRG-14) inactivated whole virus and split virion influenza vaccines and analysis of immunogenicity in mice using different adjuvant formulations.

@article{Miyaki2010ProductionOH,
  title={Production of H5N1 (NIBRG-14) inactivated whole virus and split virion influenza vaccines and analysis of immunogenicity in mice using different adjuvant formulations.},
  author={Cosue Miyaki and Wagner Quintilio and Eliane N Miyaji and Viviane Fongaro Botosso and Fl{\'a}via Saldanha Kubrusly and Fernanda Lucio dos Santos and Dmitri Iourtov and Hisako Gondo Higashi and Isa{\'i}as Raw},
  journal={Vaccine},
  year={2010},
  volume={28 13},
  pages={2505-9}
}
Consecutive lots of H5N1 (A/Vietnam/1194/2004 - NIBRG-14) split virion and whole virus vaccines were produced in a pilot-scale laboratory. The average yields of vaccine doses (15 microg HA) per egg were 0.57 doses for H5N1 split virion vaccine and 1.12 for H5N1 whole virus vaccine, compared to 2.09 doses for the seasonal H3N2 split virion vaccine. H5N1 split virion vaccine lots complied with WHO protein content criteria, while some lots of the H5N1 whole virus vaccine showed protein content per… CONTINUE READING