Corpus ID: 39560340

Production of Botulinum Toxin A BE 3340 Process Design Group 5

  title={Production of Botulinum Toxin A BE 3340 Process Design Group 5},
  author={Natalie Derise and Kristin Harrison and Christina Juneau and D Rees},
known to man, also employs a vital purpose in medical drug therapy. Through the growth, extraction, and purification of Botulinum Toxin A (BT-A) from either live cultures or spores of C. botulinum, patients suffering from a multitude of neuromuscular disorders are given more freedom to live independently and painlessly. Specifically, in the neuromuscular disorder Cerebral Palsy, an excess release of acetylcholine results in uncontrolled muscle contraction. BT-A inhibits the transfer of… Expand

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Purification of Clostridium botulinum type A neurotoxin.
Methods for production of high-quality botulinum type A toxin complex and neurotoxin are described, considered the most potent poisons known for humans and certain animals. Expand
Toxin production by Clostridium botulinum type A under various fermentation conditions
Cell lysis was apparently not required to obtain maximum toxin concentrations under the fermentation conditions described, and the maximum toxin concentration was attained within 24 h. Expand
Germination of spores from Clostridium botulinum B-aphis and Ba410
Differences in the germination kinetics of both strains could not be explained by ultrastructural differences, and transmission electron micrographs revealed striking similarities between the strains. Expand
Effectiveness of botulinum toxin A for upper and lower limb spasticity in children with cerebral palsy: a summary of evidence
There is now growing convincing evidence for the time limited beneficial effect of BoNT-A in decreasing muscle tone in children with upper and lower limbs spasticity associated with CP. Expand
Randomised double blind placebo controlled trial of the effect of botulinum toxin on walking in cerebral palsy.
The study gives further support to the use of intramuscular botulinum toxin type A as an adjunct to conventional physiotherapy and orthoses to reduce spasticity and improve functional mobility in children with spastic diplegic or hemiplegic cerebral palsy. Expand
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