Production of Both Prolactin and Growth Hormone by Clonal Strains of Rat Pituitary Tumor Cells

Abstract

Several established clonal strains of rat pituitary cells which produce growth hormone in culture have been shown to secrete a second protein hormone, prolactin. Prolactin was measured immunologically in culture medium and within cells by complement fixation. Rates of prolactin production varied from 6.6 to 12 microg/mg cell protein per 24 hr in four… (More)

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