Production of Both Prolactin and Growth Hormone by Clonal Strains of Rat Pituitary Tumor Cells

@article{Tashjian1970ProductionOB,
  title={Production of Both Prolactin and Growth Hormone by Clonal Strains of Rat Pituitary Tumor Cells},
  author={Armen H. Tashjian and Frank C. Bancroft and Lawrence Levine},
  journal={The Journal of Cell Biology},
  year={1970},
  volume={47},
  pages={61 - 70}
}
Several established clonal strains of rat pituitary cells which produce growth hormone in culture have been shown to secrete a second protein hormone, prolactin. Prolactin was measured immunologically in culture medium and within cells by complement fixation. Rates of prolactin production varied from 6.6 to 12 microg/mg cell protein per 24 hr in four different cell strains. In these cultures ratios of production of prolactin to growth hormone varied from 1.0 to 4.1. A fifth clonal strain… CONTINUE READING
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