Production of 7-O-methyl aromadendrin, a medicinally valuable flavonoid, in Escherichia coli.

@article{Malla2012ProductionO7,
  title={Production of 7-O-methyl aromadendrin, a medicinally valuable flavonoid, in Escherichia coli.},
  author={Sailesh Malla and Mattheos A G Koffas and Romas J Kazlauskas and Byung-Gee Kim},
  journal={Applied and environmental microbiology},
  year={2012},
  volume={78 3},
  pages={684-94}
}
7-O-Methyl aromadendrin (7-OMA) is an aglycone moiety of one of the important flavonoid-glycosides found in several plants, such as Populus alba and Eucalyptus maculata, with various medicinal applications. To produce such valuable natural flavonoids in large quantity, an Escherichia coli cell factory has been developed to employ various plant biosynthetic pathways. Here, we report the generation of 7-OMA from its precursor, p-coumaric acid, in E. coli for the first time. Primarily, naringenin… CONTINUE READING

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