Production of 4-hydroxybutyrate from succinate semialdehyde in butyrate biosynthesis in Porphyromonas gingivalis.

@article{Yoshida2015ProductionO4,
  title={Production of 4-hydroxybutyrate from succinate semialdehyde in butyrate biosynthesis in Porphyromonas gingivalis.},
  author={Yasuo Yoshida and Mitsunari Sato and Keiji Nagano and Yoshiaki Hasegawa and Takashi Okamoto and Fuminobu Yoshimura},
  journal={Biochimica et biophysica acta},
  year={2015},
  volume={1850 12},
  pages={
          2582-91
        }
}
BACKGROUND Despite evidence demonstrating the importance of butyrate-producing bacteria in host health and disease, the characterization of enzymes responsible for butyrate production has not been fully elucidated in the periodontopathogen, Porphyromonas gingivalis. METHODS LC-MS/MS and colorimetric analyses were employed to enzymatically characterize recombinant PGN_0724 in P. gingivalis as a succinate semialdehyde reductase. The concentration of short chain fatty acids in the culture… CONTINUE READING