• DOI:10.1088/0031-9155/59/11/2849
• Corpus ID: 21973246

Production of α-particle emitting 211At using 45 MeV α-beam

@article{Kim2014ProductionO,
  title={Production of $\alpha$-particle emitting 211At using 45 MeV $\alpha$-beam},
  author={Gyehong Kim and Kwon Soo Chun and Sung Ho Park and Byungil Kim},
  journal={Physics in Medicine and Biology},
  year={2014},
  volume={59},
  pages={2849 - 2860}
}

• Gyehong Kim, K. Chun, +1 author Byungil Kim
• Published 7 June 2014
• Physics
• Physics in Medicine and Biology

Among the α-particle emitting radionuclides, 211At is considered to be a promising radionuclide for targeted cancer therapy due to its decay properties. The range of alpha particles produced by the decay of 211At are less than 70 µm in water with a linear energy transfer between 100 and 130 keV µm−1, which are about the maximum relative biological effectiveness for heavy ions. It is important to note that at the present time, only a few of cyclotrons routinely produce 211At. The direct production method is based on the nuclear reactions 209Bi(α,2n)211At. Production of the radionuclide 211At was carried out using the MC-50 cyclotron at the Korea Institute of Radiological and Medical Sciences (KIRAMS). To ensure high beam current, the α-beam was extracted with an initial energy of 45 MeV, which was degraded to obtain the appropriate α-beam energy. The calculations of beam energy degradation were performed utilizing the MCNPX. Alumina-baked targets were prepared by heating the bismuth metal powder onto a circular cavity in a furnace. When using an Eα, av of 29.17 MeV, the very small contribution of 210At confirms the right choice of the irradiation energy to obtain a pure production of 211At isotope.