Production of α-particle emitting 211At using 45 MeV α-beam

  title={Production of $\alpha$-particle emitting 211At using 45 MeV $\alpha$-beam},
  author={Gyehong Kim and Kwon Soo Chun and Sung Ho Park and Byungil Kim},
  journal={Physics in Medicine and Biology},
  pages={2849 - 2860}
Among the α-particle emitting radionuclides, 211At is considered to be a promising radionuclide for targeted cancer therapy due to its decay properties. The range of alpha particles produced by the decay of 211At are less than 70 µm in water with a linear energy transfer between 100 and 130 keV µm−1, which are about the maximum relative biological effectiveness for heavy ions. It is important to note that at the present time, only a few of cyclotrons routinely produce 211At. The direct… 

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Targeted therapy using alpha emitters.

Results suggest that meta-[211At] astatobenzylguanidine might be valuable for the targeted radiotherapy of micrometastatic neuroblastomas.

Thick target yield measurement of 211At through the nuclear reaction 209Bi(?, 2n)

Radionuclide Therapy (RNT) and Radioimmunotherapy (RIT) are potentially of great interest for cancer therapy. In many therapeutic applications alpha emitters should be much more effective than

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    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
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A new internal target system for production of (211)At on the cyclotron U-120M.

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  • 2005

Cyclotron production of 211At/211gPo by 209Bi(α,2n) reaction

Astatine-211 (T1/2 = 7.214 h) is an α-emitter at secular equilibrium by EC with its ultra-short-lived α-emitting daughter, polonium-211g (T1/2 = 0.516 s), with a high Linear Energy Transfer (LET —

Optimisation of cyclotron production parameters for the 209Bi(alpha, 2n) 211At reaction related to biomedical use of 211At.

Assessing the 210At impurity in the production of 211At for radiotherapy by 210Po analysis via isotope dilution alpha spectrometry.

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    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
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Astatine-211: production and availability.

The 7.2-h half life radiohalogen (211)At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211