Production and targeting of the Brucella abortus antigen L7/L12 in Lactococcus lactis: a first step towards food-grade live vaccines against brucellosis.

@article{Ribeiro2002ProductionAT,
  title={Production and targeting of the Brucella abortus antigen L7/L12 in Lactococcus lactis: a first step towards food-grade live vaccines against brucellosis.},
  author={Luciana A Ribeiro and Vasco Azevedo and Yves Le Loir and Sergio Costa Oliveira and Yakhya Dieye and Jean-Christophe Piard and Alexandra Gruss and Philippe Langella},
  journal={Applied and environmental microbiology},
  year={2002},
  volume={68 2},
  pages={910-6}
}
Brucella abortus is a facultative intracellular gram-negative bacterial pathogen that infects humans and animals by entry mainly through the digestive tract. B. abortus causes abortion in pregnant cattle and undulant fever in humans. The immunogenic B. abortus ribosomal protein L7/L12 is a promising candidate antigen for the development of oral live vaccines against brucellosis, using food-grade lactic acid bacteria (LAB) as a carrier. The L7/L12 gene was expressed in Lactococcus lactis, the… CONTINUE READING

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