Production and stabilization of the trimeric influenza hemagglutinin stem domain for potentially broadly protective influenza vaccines.


The rapid dissemination of the 2009 pandemic H1N1 influenza virus emphasizes the need for universal influenza vaccines that would broadly protect against multiple mutated strains. Recent efforts have focused on the highly conserved hemagglutinin (HA) stem domain, which must undergo a significant conformational change for effective viral infection. Although… (More)
DOI: 10.1073/pnas.1308701110