Production and regulation of tumor necrosis factor alpha. A cellular and molecular analysis.

@article{Kunkel1988ProductionAR,
  title={Production and regulation of tumor necrosis factor alpha. A cellular and molecular analysis.},
  author={Steven L. Kunkel and Martin Spengler and Guim Kwon and Marc Antoine May and Daniel G. Remick},
  journal={Methods and achievements in experimental pathology},
  year={1988},
  volume={13},
  pages={
          240-59
        }
}
Tumor necrosis factor alpha is increasingly being recognized as an important macrophage-derived cytokine that possesses pleomorphic effects in both physiologic and immunologic systems. Current evidence has demonstrated that tumor necrosis factor may stimulate a plethora of cellular responses in vitro and induce multiple physiologic derangements when given in vivo. While the biologic activity of tumor necrosis factor elaborated by macrophages and macrophage cell lines in response to bacterial… CONTINUE READING