Production and pathogenicity of hepatitis C virus core gene products.

@article{Li2014ProductionAP,
  title={Production and pathogenicity of hepatitis C virus core gene products.},
  author={Huawei Colin Li and Hsin-Chieh Ma and Chendong Yang and Shih-Yen Lo},
  journal={World journal of gastroenterology},
  year={2014},
  volume={20 23},
  pages={
          7104-22
        }
}
Hepatitis C virus (HCV) is a major cause of chronic liver diseases, including steatosis, cirrhosis and hepatocellular carcinoma, and its infection is also associated with insulin resistance and type 2 diabetes mellitus. HCV, belonging to the Flaviviridae family, is a small enveloped virus whose positive-stranded RNA genome encoding a polyprotein. The HCV core protein is cleaved first at residue 191 by the host signal peptidase and further cleaved by the host signal peptide peptidase at about… CONTINUE READING
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