Production and degradation of calcitriol in renal failure rats.

@article{Hsu1987ProductionAD,
  title={Production and degradation of calcitriol in renal failure rats.},
  author={C. H. Hsu and Sanjeevkumar R. Patel and Eric W. Young and Robert U. Simpson},
  journal={The American journal of physiology},
  year={1987},
  volume={253 5 Pt 2},
  pages={F1015-9}
}
We studied the metabolism of calcitriol in renal failure achieved by nephrectomy in three groups of rats. Group 1 (n = 7) had sham operation of nephrectomy. Group 2 (n = 8) had unilateral nephrectomy. Group 3 (n = 7) had 5/6 nephrectomy. Metabolic clearance rate (MCR) and production rate (PR) of calcitriol were studied 3 wk after the surgery. Serum creatinine concentrations were increased after nephrectomy for groups 2 and 3. Endogenous plasma levels of calcitriol were not different between the… CONTINUE READING