Production and characterization of murine IgA monoclonal antibodies to the surface antigens of rhesus rotavirus.

@article{Giammarioli1996ProductionAC,
  title={Production and characterization of murine IgA monoclonal antibodies to the surface antigens of rhesus rotavirus.},
  author={Anna Maria Giammarioli and Erich R. Mackow and Lucia Fiore and Harry B Greenberg and Franco Maria Ruggeri},
  journal={Virology},
  year={1996},
  volume={225 1},
  pages={
          97-110
        }
}
Rotavirus is the single most important cause of severe diarrhea in humans and is diffuse in most animal species worldwide, and an understanding of the antigenic properties of the virus is essential to the design of rational vaccine strategies. To better understand the localization of viral epitopes involved in antibody-mediated neutralization of virus infectivity, we have orally immunized mice with live rhesus rotavirus (RRV) and generated a panel of hybridoma cell clones secreting IgA class… CONTINUE READING

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