Production and characterization of monoclonal antibodies against the lethal factor component of Bacillus anthracis lethal toxin.

@article{Little1990ProductionAC,
  title={Production and characterization of monoclonal antibodies against the lethal factor component of Bacillus anthracis lethal toxin.},
  author={Stephen F. Little and Stephen H Leppla and Arthur M. Friedlander},
  journal={Infection and immunity},
  year={1990},
  volume={58 6},
  pages={1606-13}
}
The lethal toxin of Bacillus anthracis consists of two components, protective antigen and lethal factor. Protective antigen is cleaved after binding to cell receptors, yielding a receptor-bound fragment that binds lethal factor. Sixty-one monoclonal antibodies to the lethal factor protein have been characterized for specificity, antibody subtype, and ability to neutralize lethal toxin. Three monoclonal antibodies (10G3, 2E7, and 3F6) neutralized lethal toxin in Fisher 344 rats. However, in a… CONTINUE READING

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