Production and characterization of four anti-neuropeptide Y monoclonal antibodies.

  title={Production and characterization of four anti-neuropeptide Y monoclonal antibodies.},
  author={Eric Grouzmann and Etienne Comoy and Peter Walker and Michel Burnier and Claude Bohuon and Bernard Waeber and Hans Rudolf Brunner},
  volume={11 4},
Human neuropeptide Y (hNPY) is a potent vasoconstrictor peptide of 36 aminoacid residues. We isolated hybridomas secreting four monoclonal antibodies directed against various epitopes of neuropeptide Y and studied their cross-reactivity with peptide YY (PYY) and the pancreatic polypeptide (PP), two peptides sharing sequence homologies with hNPY (respectively 70% and 50%). The antibody NPY02 is an IgG1 with a Ka of 5.5 x 10(10) liters/mol. It binds to the 11-24 region of NPY (IC50 = 2 x 10(-7)M… CONTINUE READING
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