Production and characterization of an orally immunogenic Plasmodium antigen in plants using a virus-based expression system.

@article{Webster2009ProductionAC,
  title={Production and characterization of an orally immunogenic Plasmodium antigen in plants using a virus-based expression system.},
  author={D. E. Webster and Li-na Wang and Mark Mulcair and Charles Hansen Ma and Luca Santi and Hugh S Mason and Steve Lodewijk Wesselingh and Ross L Coppel},
  journal={Plant biotechnology journal},
  year={2009},
  volume={7 9},
  pages={846-55}
}
Increasing numbers of plant-made vaccines and pharmaceuticals are entering the late stage of product development and commercialization. Despite the theoretical benefits of such production, expression of parasite antigens in plants, particularly those from Plasmodium, the causative parasites for malaria, have achieved only limited success. We have previously shown that stable transformation of tobacco plants with a plant-codon optimized form of the Plasmodium yoelii merozoite surface protein 4/5… CONTINUE READING
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