Production and characterization of Clostridium perfringens recombinant β toxoid.

Abstract

In this work, we produced and evaluated a vaccine based on a β toxoid of Clostridium perfringens type C produced in Escherichia coli (rBT). The non-toxic rBT was innocuous for mice and induced 14 IU mL(-1) of β antitoxin in rabbits, complying with the European Pharmacopeia and CFR9 - USDA guidelines.

DOI: 10.1016/j.anaerobe.2012.01.004

Cite this paper

@article{Milach2012ProductionAC, title={Production and characterization of Clostridium perfringens recombinant β toxoid.}, author={Adalgisa Milach and Jo{\~a}o Rodrigo Gil de los Santos and Carlos Gil Turnes and {\^A}ngela Nunes Moreira and Ronnie Antunes de Assis and Felipe Masiero Salvarani and Francisco Carlos Faria Lobato and Fabr{\'i}cio Rochedo Conceiç{\~a}o}, journal={Anaerobe}, year={2012}, volume={18 3}, pages={363-5} }