Production and activation of matrix metalloproteinase 7 (matrilysin 1) in the lungs of patients with idiopathic pulmonary fibrosis.

@article{Fujishima2010ProductionAA,
  title={Production and activation of matrix metalloproteinase 7 (matrilysin 1) in the lungs of patients with idiopathic pulmonary fibrosis.},
  author={Seitaro Fujishima and Takayuki Shiomi and Shuji Yamashita and Yurika Yogo and Yasushi Nakano and Takashi Inoue and Morio Nakamura and Sadatomo Tasaka and Naoki Hasegawa and Naoki Aikawa and Akitoshi Ishizaka and Yasunori Okada},
  journal={Archives of pathology & laboratory medicine},
  year={2010},
  volume={134 8},
  pages={1136-42}
}
CONTEXT Idiopathic pulmonary fibrosis (IPF) is characterized by diffuse interstitial inflammation and fibroblast proliferation with accelerated remodeling of extracellular matrix, which result in irreversible destruction of the lung's architecture. OBJECTIVE To elucidate the production levels, tissue localization, and activation of matrix metalloproteinase 7 (MMP-7) in the lungs of patients with IPF. DESIGN Bronchoalveolar lavage analysis was performed in 17 IPF patients and 6 healthy… CONTINUE READING