Production and action of insulin-like growth factor I/somatomedin C in primary cultures of fetal lung fibroblasts.

@article{Stiles1989ProductionAA,
  title={Production and action of insulin-like growth factor I/somatomedin C in primary cultures of fetal lung fibroblasts.},
  author={Alan D Stiles and Billie M. Moats-Staats},
  journal={American journal of respiratory cell and molecular biology},
  year={1989},
  volume={1 1},
  pages={21-6}
}
Production of insulin-like growth factor I/somatomedin C (IGF-I) by 19-day-gestation fetal rat lung fibroblasts was studied, and a paracrine (local production and action) mitogenic activity of this growth factor was explored. Specific IGF-I mRNAs were demonstrated in these cells, consistent with production of IGF-I. Using an IGF-I monoclonal antibody, IGF-I-like material was isolated from fetal lung fibroblast conditioned medium (FCM) and separated by molecular weight. Several molecular weight… CONTINUE READING

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