Production and Mode of Action of Lactocin 27: Bacteriocin from a Homofermentative Lactobacillus

@article{Upreti1975ProductionAM,
  title={Production and Mode of Action of Lactocin 27: Bacteriocin from a Homofermentative Lactobacillus},
  author={Girish C. Upreti and Ronald D. Hinsdill},
  journal={Antimicrobial Agents and Chemotherapy},
  year={1975},
  volume={7},
  pages={139 - 145}
}
  • G. Upreti, R. Hinsdill
  • Published 1 February 1975
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
Lactobacillus helveticus strain LP27 produced a bacteriocin, lactocin 27, in dialyzable and nondialyzable forms. No evidence was obtained to indicate that lactocin 27 was under the control of extrachromosomal plasmids. Lactocin 27 had a bacteriostatic effect on the indicator, Lactobacillus helveticus strain LS18. It inhibited primarily protein synthesis without affecting deoxyribonucleic acid and ribonucleic acid synthesis or adenosine 5′-triphosphate levels. Treatment of susceptible cells with… 

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Nearly 100 isolates of Lactobacillus were obtained from human and animal sources and one of these, L. helveticus strain LP27, was shown to produce a potent bacteriocin called lactocin 27, which was isolated from the culture supernatant fluid as a protein-lipopolysaccharide complex.
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