• Corpus ID: 46029269

Production, isolation, and synthesis of the coumermycins (sugordomycins), a new streptomycete antibiotic complex.

@article{Berger1965ProductionIA,
  title={Production, isolation, and synthesis of the coumermycins (sugordomycins), a new streptomycete antibiotic complex.},
  author={J Berger and Arno J. Schocher and Andrew D. Batcho and Benjamin Pecherer and Oscar Keller and Jean Maricq and Andrew E. Karr and B P Vaterlaus and Andre Furlenmeier and H Speigelberg},
  journal={Antimicrobial agents and chemotherapy},
  year={1965},
  volume={5},
  pages={
          778-85
        }
}

A New-Class Antibacterial-Almost. Lessons in Drug Discovery and Development: A Critical Analysis of More than 50 Years of Effort toward ATPase Inhibitors of DNA Gyrase and Topoisomerase IV.

TLDR
The technical understanding of the molecular details of the inhibition of the gyrase and topo IV ATPases, the factors governing resistance development to such inhibitors, and the knowledge of the physical properties required for robust clinical drug candidates have all matured to the point wherein the industry may address this mechanism of action with greater confidence.

Monopyrrolic natural compounds including tetramic acid derivatives.

  • A. Gossauer
  • Chemistry
    Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progres dans la chimie des substances organiques naturelles
  • 2003
TLDR
Of great significance, therefore, was the observation made by Sachs in 1931 that the urine of patients affected by acute porphyria gives a positive Ehrlich reaction, which is characteristic for pyrrole and its derivatives.

The naturally occurring coumarins.

  • R. D. Murray
  • Chemistry, Medicine
    Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progres dans la chimie des substances organiques naturelles
  • 2002

Synergistic Inhibition of Human Immunodeficiency Virus Type 1 in vitro by Interferon Alpha and Coumermycin A1

TLDR
It is found that combinations of these two agents synergistically inhibited HIV replication in human peripheral blood leucocytes (PBL).

Investigation of Topoisomerase Inhibitors for Activity against Human Immunodeficiency Virus: Inhibition by Coumermycin A1

TLDR
Coumermycin A1 did not inhibit HIV reverse transcriptase activity in an in vitro assay at concentrations that inhibited HIV replication in infected cells; its precise mechanism of action remains to be elucidated.

Synthesis and in vitro activity of new semi-synthetic coumermycin analogs: chemical modification at the C-3 amide.

Several new semi-synthetic coumermycin analogs, which carry a polar substituent at the C-3 amide moiety have been prepared. In vitro antibacterial activity of these new analogs against Gram-positive

Treatment of Staphylococcus aureus endocarditis in rats with coumermycin A1 and ciprofloxacin, alone or in combination

TLDR
The results suggested that coumermycin might not be adequate for the treatment of serious s.

Coumermycin: in vitro activity against 251 clinical isolates of bacteria compared with the activities of eight other antibacterial agents.

TLDR
The in vitro activity of coumermycin has been compared with those of ampicillin, clindamycin, cloxacillin, doxycycline, erythromycin, netilmicin, penicillin G and vancomycin, and showed poor activity against S. pyogenes, S. pneumoniae, Streptococcus pneumoniae and enterococci.