Production, isolation, and identification of dihydroepiepoformin as an IL-1 receptor antagonistic component in Penicillium patulum.

@article{Kuo1995ProductionIA,
  title={Production, isolation, and identification of dihydroepiepoformin as an IL-1 receptor antagonistic component in Penicillium patulum.},
  author={Ming-shang Kuo and David A. Yurek and Stephen A. Mizsak and Vincent P. Marshall and Walter F. Liggett and Joyce I. Cialdella and Alice L. Laborde and John A. Shelly and S E Truesdell},
  journal={The Journal of antibiotics},
  year={1995},
  volume={48 8},
  pages={
          888-90
        }
}
extracted twice with an equal volume of ethyl acetate. The organic layer after concentration was dissolved in MeOH/waterand passed through a column of Diaion HP-20. The column was eluted with a stepwise water/ MeOHgradient. Active fractions were combined, freezedried, and dry-packed to a silica column. Elution with a CH2Cl2/MeOH gradient resolved the activity into gentisyl alcohol and mixture of EEF and DHEEF. The separation of DHEEFfrom EEF was achieved by using preparative HPLC(Waters Prep… 
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