Production, degradation, and circulating levels of 1,25-dihydroxyvitamin D in health and in chronic glucocorticoid excess.

@article{Seeman1980ProductionDA,
  title={Production, degradation, and circulating levels of 1,25-dihydroxyvitamin D in health and in chronic glucocorticoid excess.},
  author={E. R. BernsteinJeffrey I. Seeman and Rajiv Kumar and Gene G. Hunder and Mary Scott and Hunter Heath and B. Lawrence Riggs},
  journal={The Journal of clinical investigation},
  year={1980},
  volume={66 4},
  pages={664-9}
}
The decreased intestinal absorption of calcium and accelerated bone loss associated with chronic glucocorticoid excess may be mediated by changes in vitamin D metabolism, leading to decreased availability of circulating 1,25-dihydroxyvitamin D. This hypothesis was examined in 14 patients with either endogenous or exogenous glucocorticoid excess. Analysis of paired serum samples (mean +/- SE) in 13 patients during euglucocorticoidism and during hyperglucocorticoidism showed that glucocorticoid… CONTINUE READING