Production, characterization and control of MenB-vaccine "Folkehelsa": an outer membrane vesicle vaccine against group B meningococcal disease.

@article{Fredriksen1991ProductionCA,
  title={Production, characterization and control of MenB-vaccine "Folkehelsa": an outer membrane vesicle vaccine against group B meningococcal disease.},
  author={J H Fredriksen and Einar Rosenqvist and Elisabeth Wedege and Klaus Bryn and Gunnar Bjune and Leif Oddvar Fr\oholm and A K Lindbak and B M\ogster and Ellen Namork and U Rye},
  journal={NIPH annals},
  year={1991},
  volume={14 2},
  pages={67-79; discussion 79-80}
}
A vaccine against serogroup B meningococcal disease has been prepared from a B:15:P1.7,16 meningococcal strain (44/76) by fermentor growth and extraction of the bacteria with the detergent deoxycholate. Outer membrane vesicles (OMV) were purified by ultracentrifugation and adsorbed to aluminium hydroxide adjuvant. OMV contained the major class 1, 3, 4 and 5 proteins and some minor high molecular weight protein components. Relative to protein, the vaccine also contained about 8% phospholipid, 7… CONTINUE READING
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