Production, characterization and control of a Neisseria meningitidis hexavalent class 1 outer membrane protein containing vesicle vaccine.

@article{Claassen1996ProductionCA,
  title={Production, characterization and control of a Neisseria meningitidis hexavalent class 1 outer membrane protein containing vesicle vaccine.},
  author={I J T M Claassen and J Meylis and Peter van der Ley and Cacha Peeters and H F Brons and J Robert and Denny Borsboom and Arno van der Ark and Ineke van Straaten and Paul J. M. Roholl and Betsy Kuipers and J Bart Poolman},
  journal={Vaccine},
  year={1996},
  volume={14 10},
  pages={1001-8}
}
An experimental serogroup B meningococcal vaccine was prepared from two genetically engineered strains; each expressing three different class 1 outer membrane proteins (OMPs) (PorA). The two strains expressed the subtypes P1.7,16;P1.5,2;P1.19,15 and P1.5c,10;P1.12,13;P1.7h,4, respectively. Outer membrane vesicles (OMV) were prepared from these strains by deoxycholate extraction, mixed with aluminiumphosphate as adjuvant and formulated to final vaccines. The class 1 OMPs represent ca 90% of the… CONTINUE READING
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