Production, characterization, and epitope mapping of a monoclonal antibody against aspartic proteinase of Candida albicans.

@article{Na1999ProductionCA,
  title={Production, characterization, and epitope mapping of a monoclonal antibody against aspartic proteinase of Candida albicans.},
  author={B. K. Na and Gyung Tae Chung and Chul Yong Song},
  journal={Clinical and diagnostic laboratory immunology},
  year={1999},
  volume={6 3},
  pages={429-33}
}
A monoclonal antibody (MAb; MAb CAP1) that was reactive with extracellular aspartic proteinase of Candida albicans (CAP) was produced. The MAb showed strong sensitivity and reactivity to CAP but not to the aspartic proteinases of Candida parapsilosis, Candida tropicalis, and Aspergillus fumigatus or to human cathepsin D or porcine pepsin. The epitope of the CAP recognized by the MAb was the proteinaseous part of CAP and the putative epitope of the MAb was located in the Asp77 to Gly103 sequence… CONTINUE READING