Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates

@article{Bustelo1992ProductOV,
  title={Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates},
  author={Xos{\'e} R Bustelo and Jeffrey A. Ledbetter and Mariano Barbacid},
  journal={Nature},
  year={1992},
  volume={356},
  pages={68-71}
}
SEVERAL proteins implicated in the regulation of cellular responses to mitogenic stimuli contain a common non-catalytic domain, SH2 (for src-homologous domain 2), that mediates their interaction with activated tyrosine protein kinases. Here we report that p95 vav , a proto-oncogene product specifically expressed in cells of the haematopoietic system, contains an SH2 domain and is a substrate for tyrosine protein kinases. Exposure of quiescent NIH3T3 cells ectopically expressing p95 vav to… CONTINUE READING

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