Producer vs. parental cell – metabolic changes and burden upon α1-antitrypsin production in AGE1.HN®

Abstract

Background The human designer cell line AGE1.HN represents a promising production system for biopharmaceuticals, particularly for those needing human-type post-translational modifications [1,2]. For further rational improvement of the cell line and the cultivation process a detailed understanding of the metabolism and metabolic changes during glycoprotein… (More)
DOI: 10.1186/1753-6561-5-S8-P85

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