Prodrugs. Do they have advantages in clinical practice?

@article{Stella1985ProdrugsDT,
  title={Prodrugs. Do they have advantages in clinical practice?},
  author={Valentino J. Stella and William N. Charman and Vijay H. Naringrekar},
  journal={Drugs},
  year={1985},
  volume={29 5},
  pages={
          455-73
        }
}
Prodrugs are pharmacologically inactive chemical derivatives of a drug molecule that require a transformation within the body in order to release the active drug. They are designed to overcome pharmaceutical and/or pharmacokinetically based problems associated with the parent drug molecule that would otherwise limit the clinical usefulness of the drug. The scientific rationale, based on clinical, pharmaceutical and chemical experience, for the design of various currently used prodrugs is… 
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TLDR
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