Prodrugs. Do they have advantages in clinical practice?
@article{Stella1985ProdrugsDT, title={Prodrugs. Do they have advantages in clinical practice?}, author={Valentino J. Stella and William N. Charman and Vijay H. Naringrekar}, journal={Drugs}, year={1985}, volume={29 5}, pages={ 455-73 } }
Prodrugs are pharmacologically inactive chemical derivatives of a drug molecule that require a transformation within the body in order to release the active drug. They are designed to overcome pharmaceutical and/or pharmacokinetically based problems associated with the parent drug molecule that would otherwise limit the clinical usefulness of the drug. The scientific rationale, based on clinical, pharmaceutical and chemical experience, for the design of various currently used prodrugs is…
186 Citations
Prodrugs: design and clinical applications
- Biology, ChemistryNature Reviews Drug Discovery
- 2008
The most common functional groups that are amenable to prodrug design are described, and examples of prodrugs that are either launched or are undergoing human trials are highlighted.
PRODRUGS: A REVIEW
- Biology, Chemistry
- 2014
Classification, effect of prodrug on solubility, chemical stability, bioavailability, long duration of action and site targeted challenge with examples of pro drug illustrating the role of produg as a better way for the more effective treatment of different diseases are included.
Design and Pharmaceutical Applications of Prodrugs
- Biology, Chemistry
- 2010
The design and pharmaceutical applications of prodrugs are studied, which aims to overcome limitations of a parent drug that would otherwise hinder its clinical use.
Prodrug Approach: An Alternative to Improve Pharmacokinetic Properties
- Biology, ChemistryInternational Journal of Bioorganic Chemistry
- 2019
This review introduces in depth the rationale behind the use of the promoiety, and also considers the possible problems that can arise from inadequate activation of prodrugs.
Prodrug Design by Computation Methods: A New Era
- Biology, Chemistry
- 2013
Prodrugs, soft drugs, targeted drugs, and metabolites of drugs are common terms that are used in the pharmaceutical field and can be enzymatically or chemically converted in vivo to provide the parent active drug to exert a therapeutic effect.
Highly Efficient Prodrugs: Design and Therapeutic Applications
- Biology, ChemistryOriental Journal Of Chemistry
- 2020
In this review, different types of carriers, which can be used for prodrug synthesis are summarized and both marketed and investigational prodrugs from several promoieties are discussed not only for their advantages and uses but also their prospects.
Prodrugs available on the Brazilian pharmaceutical market and their corresponding bioactivation pathways
- Biology
- 2010
Examination of examples of prodrugs from many important therapeutic classes shows that prodrug design is a very valuable aspect in the research of new drugs and for the pharmaceutical industry as a whole.
Cutting Edge Approach on Prodrug: Contrivance for Target Drug Delivery
- Biology
- 2011
Prodrugs are the shrouded drugs which are one or two chemical or enzymatic steps away from the active parent drug.
Prodrug Approaches for CNS Delivery
- Biology, ChemistryThe AAPS Journal
- 2008
Insight is provided into various prodrug strategies explored to date for CNS drug delivery, including lipophilic prodrugs, carrier- and receptor-mediated prodrug delivery systems, and gene-directed enzyme prodrug therapy.
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