Prodrugs of anthracyclines in cancer chemotherapy.

@article{Kratz2006ProdrugsOA,
  title={Prodrugs of anthracyclines in cancer chemotherapy.},
  author={Felix Kratz and Andreas Warnecke and Benedikt Schmid and D-E Chung and M Gitzel},
  journal={Current medicinal chemistry},
  year={2006},
  volume={13 5},
  pages={
          477-523
        }
}
Designing and developing truly tumor-specific prodrugs remains a challenge in the field of cancer chemotherapy. Active targeting strategies, on the one hand, aim at exploiting membrane-associated receptors or antigens for drug delivery; on the other hand, the enhanced vascular permeability and retention of macromolecules in tumor tissue substantiates the concept of passive targeting. Consequently, research efforts have concentrated on conjugating anticancer agents with a wide spectrum of… CONTINUE READING
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