Prodrugs in cancer chemotherapy

@article{Knox1986ProdrugsIC,
  title={Prodrugs in cancer chemotherapy},
  author={Richard J. Knox and Tom A Connors},
  journal={Pathology & Oncology Research},
  year={1986},
  volume={3},
  pages={309-324}
}
At present, chemotherapy is not very effective against common solid cancers especially once they have metastasised. However, laboratory experiments and studies on dose intensification in humans have indicated that some anti-cancer agents might be curative but only if the dose given was very much higher than that presently obtainable clinically. Prodrugs, activated by enzymes expressed at raised level in tumors, can deliver at least 50-fold the normal dose and can cure animals with tumors… CONTINUE READING

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