Prodrug and conjugate drug delivery strategies for improving HIV/AIDS therapy.

@article{Palombo2009ProdrugAC,
  title={Prodrug and conjugate drug delivery strategies for improving HIV/AIDS therapy.},
  author={Matthew S. Palombo and Yagespari Singh and Patrick J. Sinko},
  journal={Journal of drug delivery science and technology},
  year={2009},
  volume={19 1},
  pages={3-14}
}
Despite the wide variety of highly potent anti-HIV drugs that have been developed and made available in clinical practice over the years, eradication of HIV infection has not been achieved. Currently, HIV infection and AIDS are thought to be chronically treatable. HIV attacks host immune cells namely macrophages and CD4(+)T-cells and sequesters itself into sanctuary and reservoir sites such as the lymphoid tissues, testes, and brain. Initial drug delivery efforts with prodrugs and drug… CONTINUE READING