Prodrug-Like, PEGylated Protein Toxin Trichosanthin for Reversal of Chemoresistance.

  title={Prodrug-Like, PEGylated Protein Toxin Trichosanthin for Reversal of Chemoresistance.},
  author={Yingzhi Chen and Meng Zhang and Hongyue Jin and Yisi Tang and Aihua Wu and Qin Xu and Yongzhuo Huang},
  journal={Molecular pharmaceutics},
  volume={14 5},
Multidrug resistance (MDR) is a main obstacle in cancer chemotherapy. The MDR mechanisms involve P-glycoprotein (P-gp) overexpression, abnormality of apoptosis-related protein, and altered expression of drug-targeting proteins. Therapeutic proteins are emerging as candidates for overcoming cancer MDR because of not only their large molecular size that potentially circumvents the P-gp-mediated drug efflux but also their distinctive bioactivity distinguished from small-molecular drugs. Herein we… CONTINUE READING

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