Prodrug Approaches for CNS Delivery

  title={Prodrug Approaches for CNS Delivery},
  author={Jarkko Rautio and Krista Laine and Mikko Gynther and Jouko Savolainen},
  journal={The AAPS Journal},
Central nervous system (CNS) drug delivery remains a major challenge, despite extensive efforts that have been made to develop novel strategies to overcome obstacles. Prodrugs are bioreversible derivatives of drug molecules that must undergo an enzymatic and/or chemical transformation in vivo to release the active parent drug, which subsequently exerts the desired pharmacological effect. In both drug discovery and drug development, prodrugs have become an established tool for improving… CONTINUE READING